Illicit object detection is a critical task performed at various high-security locations, including airports, train stations, subways, and ports. The continuous and tedious work of examining thousands of X-ray images per hour can be mentally taxing. Thus, Deep Neural Networks (DNNs) can be used to automate the X-ray image analysis process, improve efficiency a nd alleviate t he security o fficers' in spection burden. The neural architectures typically utilized in relevant literature are Convolutional Neural Networks (CNNs), with Vision Transformers (ViTs) rarely employed. In order to address this gap, this paper conducts a comprehensive evaluation of relevant ViT architectures on illicit item detection in X-ray images. This study utilizes both Transformer and hybrid backbones, such as SWIN and NextViT, and detectors, such as DINO and RT-DETR. The results demonstrate the remarkable accuracy of the DINO Transformer detector in the low-data regime, the impressive real-time performance of YOLOv8, and the effectiveness of the hybrid NextViT backbone.