Common artefacts such as baseline drift, rescaling, and noise critically limit the performance of machine learning-based automated ECG analysis and interpretation. This study proposes Derived Peak (DP) encoding, a non-parametric method that generates signed spikes corresponding to zero crossings of the signal’s first and second-order time derivatives. Notably, DP encoding is invariant to shift and scaling artefacts, and its implementation is further simplified by the absence of user-defined parameters. DP encoding was used to encode the 12-lead ECG data from the PTB-XL dataset (n=18,869 participants) and was fed to 1D-ResNet-18 models trained to identify myocardial infarction, conductive deficits and ST-segment abnormalities. Robustness to artefacts was assessed by corrupting ECG data with sinusoidal baseline drift, shift, rescaling and noise, before encoding. The addition of these artefacts resulted in a significant drop in accuracy for seven other methods from prior art, while DP encoding maintained a baseline AUC of 0.88 under drift, shift and rescaling. DP achieved superior performance to unencoded inputs in the presence of shift (AUC under 1 mV shift: 0.91 vs 0.62), and rescaling artefacts (AUC 0.91 vs 0.79). Thus, DP encoding is a simple method by which robustness to common ECG artefacts may be improved for automated ECG analysis and interpretation.