Generalizable semantic segmentation, aims to excel on unseen target domains, as a critical focus due to the widespread practical applications requiring high generalizability. Class-wise prototypes, which depict class-wise centroids, as a type of domain-invariant information are key to improving the model generalizability due to its stability and representativeness. However, this manner faces some challenges. First, the existing methods adopt a coarse prototypical alignment form, potentially compromising performance. Second, the naive prototype generally serves as the class centroid generated by an average operation from source data batches, risks source domain overfitting, and may be detrimentally impacted by unrelated source data. Third, from a broader perspective, rather than just from a prototypical alignment perspective, the existing methods treat all samples equally, which is against the conclusion that different source features have different adaptation difficulties. To tackle these issues, we propose a novel method for generalizable semantic segmentation called Prototypical Progressive Alignment and Reweighting (PPAR) depending on the strong generalized representation of the Contrastive Language-Image Pretraining (CLIP) model. In particular, we first define the Original Text Prototype (OTP) and Visual Text Prototype (VTP) generated by the CLIP model, laying the foundation for the subsequent effective alignment strategy. Then, we propose a prototypical progressive alignment strategy by an easy-to-difficult alignment form to reduce domain-variant information progressively instead of directly. Finally, we propose a prototypical reweighting learning strategy that estimates the importance of the source data and corrects its learning weight to alleviate the influence of unrelated source features, i.e. alleviate negative transfer. Moreover, we also offer a theoretical insight into our method and it shows that our method compiles well on the domain generalization theory. Extensive experiments on several popular datasets demonstrate that our PPAR method achieves superior performance, proving the effectiveness of our method. The source code will available at: https://github.com/Hectoor/PPAR