GAFR-Net: A Graph Attention and Fuzzy-Rule Network for Interpretable Breast Cancer Image Classification

Accurate classification of breast cancer histopathology images is essential for early diagnosis and effective clinical management. However, conventional deep learning models often exhibit performance degradation under limited labeled data and lack interpretability, which restricts their clinical applicability. To address these challenges, we propose GAFR-Net, a robust and interpretable Graph Attention and Fuzzy-Rule Network designed for histopathology image classification under scarce supervision (defined here as less than 10% labeled data). GAFR-Net constructs a similarity-driven graph to model inter-sample relationships and employs a multi-head graph attention mechanism to capture complex relational representations among heterogeneous tissue structures. Meanwhile, a differentiable fuzzy-rule module integrates intrinsic topological descriptors—such as node degree, clustering coefficient, and label consistency—into explicit and human-readable diagnostic rules. This architecture establishes transparent IF–THEN inference mappings that emulate the heuristic reasoning process of clinical experts, thereby enhancing model interpretability without relying on post-hoc explanation techniques. Extensive experiments conducted on three public benchmark datasets—BreakHis, Mini-DDSM, and ICIAR2018—demonstrate that GAFR-Net consistently surpasses state-of-the-art methods across multiple magnifications and classification settings. These results highlight the strong generalization capability and practical potential of GAFR-Net as a trustworthy decision-support framework for weakly supervised medical image analysis.