In this work, we explore the role of synthetic data in improving the detection of Hand-Object Interactions from egocentric images. Through extensive experimentation and comparative analysis on VISOR, EgoHOS, and ENIGMA-51 datasets, our findings demonstrate the potential of synthetic data to significantly improve HOI detection, particularly when real labeled data are scarce or unavailable. By using synthetic data and only 10%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$10\%$$\end{document} of the real labeled data, we achieve improvements in Overall AP over models trained exclusively on real data, with gains of +5.67%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$+5.67\%$$\end{document} on VISOR, +8.24%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$+8.24\%$$\end{document} on EgoHOS, and +11.69%\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$+11.69\%$$\end{document} on ENIGMA-51. Furthermore, we systematically study how aligning synthetic data to specific real-world benchmarks with respect to objects, grasps, and environments, showing that the effectiveness of synthetic data consistently improves with better synthetic-real alignment. As a result of this work, we release a new data generation pipeline and the new HOI-Synth benchmark, which augments existing datasets with synthetic images of hand-object interaction. These data are automatically annotated with hand-object contact states, bounding boxes, and pixel-wise segmentation masks. All data, code, and tools for synthetic data generation are available at: https://fpv-iplab.github.io/HOI-Synth/.