Single-shot quantum neural networks with amplitude estimation

Quantum neural networks (QNNs) suffer from a fundamental sampling bottleneck since quantum measurements are probabilistic, requiring many circuit executions to estimate outputs with sufficient accuracy. Conventional Monte-Carlo (MC) inference exhibits an $\mathcal{O}(1/\sqrt{N})$ sampling error, rendering QNN inference and training costly on near-term quantum hardware, especially where each shot requires expensive qubit generation. This work introduces a"single-shot"QNN framework by integrating quantum amplitude estimation (AE) into the readout stage. By embedding a trained QNN as a state-preparation oracle within AE, outputs are estimated through coherent interference rather than repeated sampling. We demonstrate that AE-based QNN inference achieves an $\mathcal{O}(1/N)$ error even with a single shot. We further analyze noise robustness and training feasibility, showing that AE can be a powerful primitive for overcoming the sampling overhead of QNNs. This highlights that when the model itself is quantum, quantum algorithms can enhance the computation efficiency.