Bipartite Gaussian boson sampling (BipartiteGBS) produces output probabilities governed by squared permanents of submatrices of arbitrary complex matrices, matching the nonsymmetric structure of directed graphs. Most GBS-based graph algorithms, however, rely on symmetric hafnian structure and are formulated for undirected problems. Here we propose a BipartiteGBS-based framework for directed-graph heuristic optimization. We introduce Max-Perm as a canonical optimization task for BipartiteGBS and derive a closed-form sampling enhancement factor relative to uniform classical sampling in this idealized setting. We then use permanent-biased BipartiteGBS samples to guide a genetic algorithm for the celebrated directed Hamiltonian cycle problem. Numerical experiments on Erdős--Rényi random directed graphs show that the resulting BipartiteGBS-enhanced algorithms improve success rates over a standard genetic algorithm and yield longer valid paths when no Hamiltonian cycle is found, while ablation tests indicate that BipartiteGBS-guided initialization is the dominant contributor. These results show how permanent-based photonic sampling can provide useful algorithmic guidance for asymmetric combinatorial search.