This chapter explores the transformative role of artificial intelligence (AI) in enabling personalized learning (PL). It draws on the theoretical foundations of constructivism, multiple intelligences, self-determination theory, connectivism, and data-driven decision-making to examine how AI supports learner engagement, autonomy, and self-regulation. It highlights intelligent tutoring systems, recommender engines, emotion-aware tools, and real-time feedback systems, which furnish relevant and adaptable learning pathways. Global case studies – such as Summit Public Schools, Carnegie Learning, Squirrel AI, and David Game College – are discussed to illustrate the effectiveness of these data-driven, human-AI collaboration-based, and scalable adaptive personalized instructional systems. The chapter also addresses ethical, pedagogical, and human-related implications and emphasizes the challenges related to algorithm bias, data privacy, and teacher readiness. Emerging trends, like the integration of AI with extended reality (XR) environments that aim toward a more immersive, experiential, and evidence-based learning, are also discussed.
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