Personal Analysis And Chronotherapy

A system, method and article of manufacture are presented for improving therapy such as adjustment of a chronotherapeutic pharmaceutical regimen. Physiological variables are measured longitudinally and a time series of the measurements is constructed. In some cases, a time series is pre-whitened and transformed to a frequency spectrum while applying multi-taper filtering, and entropy or other statistical measures are calculated for the power spectral distribution. Improved timing, medication and dosage are individually or collectively improved and/or verified through successive testing. An improvement is illustrated for hypertension, using medication to achieve autonomic control and to reduce blood pressure variability and to reduce spectral diversion.