CHARACTERIZATION OF ADAPTIVE IMMUNE RESPONSE TO VACCINATION OR INFECTION USING IMMUNE REPERTOIRE SEQUENCING

Patent №

US 11,066,705

Granted

2021-07-20

Filed 2017

Owner

ADAPTIVE BIOTECHNOLOGIES CORP.

+2 more

Lab

—

AI components

hardware

Assignment

Recorded

Dataset

AIPD

2023_r1 edition

Application

15529943

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Methods of monitoring and measuring dynamic adaptive immune cell responses are provided. High-throughput sequencing of T cell receptor and immunoglobulin loci is used to characterize the breadth of an effector cell response to a stimulus, such as a vaccine or infection. Unique responding effector cell clones and abundance thereof can be determined. Additionally, methods for determining the contribution of responding effector cells to the immunological memory compartment are provided.

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Ownership

ADAPTIVE BIOTECHNOLOGIES CORP.

assignment · 439730235

FRED HUTCHINSON CANCER RESEARCH CENTER

assignment · 439730374

FRED HUTCHINSON CANCER CENTER

merger · 609820053

Assignors

DEWITT, WILLIAM SUMNER, III, EMERSON, RYAN O.

On an employer assignment, the assignors are typically the inventors.

From the same owner

METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSISUS 11,001,895 · 2021 MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILESUS 10,865,453 · 2020 MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILESUS 10,519,511 · 2019 METHOD OF DETERMINING CLONOTYPES AND CLONOTYPE PROFILESUS 9,043,160 · 2015 ADAPTIVE IMMUNITY PROFILING AND METHODS FOR GENERATION OF MONOCLONAL ANTIBODIESUS 8,685,898 · 2014

Cites (21)

METHOD OF MEASURING ADAPTIVE IMMUNITYUS 9,809,813 · 2017 MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILESUS 9,512,487 · 2016 MONITORING HEALTH AND DISEASE STATUS USING CLONOTYPE PROFILESUS 9,416,420 · 2016 METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSISUS 9,217,176 · 2015 METHOD OF DETERMINING CLONOTYPES AND CLONOTYPE PROFILESUS 9,043,160 · 2015 Digital Counting of Individual Molecules by Stochastic Attachment of Diverse LabelsUS 8,835,358 · 2014 OBTAINING USER REACTIONS TO VIDEOUS 8,826,321 · 2014 Nucleic Acid Analysis Using Sequence TokensUS 8,445,205 · 2013 CAPTURE AGENTS AND RELATED METHODS AND SYSTEMS FOR DETECTING AND/OR SORTING TARGETSUS 8,394,590 · 2013 METHODS AND COMPOSITIONS FOR TAGGING AND IDENTIFYING POLYNUCLEOTIDESUS 8,318,433 · 2012 METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSISUS 8,236,503 · 2012 NUCLEIC ACID ANALYSIS USING SEQUENCE TOKENSUS 8,021,842 · 2011 NUCLEIC ACID ANALYSIS USING SEQUENCE TOKENSUS 7,544,473 · 2009 MOLECULAR COUNTINGUS 7,537,897 · 2009 METHODS AND COMPOSITIONS FOR TAGGING AND IDENTIFYING POLYNUCLEOTIDESUS 7,393,665 · 2008 MULTIPLEXED ANALYTICAL PLATFORMUS 7,365,179 · 2008 GENETIC ANALYSIS AND AUTHENTICATIONUS 7,157,228 · 2007 IDENTIFICATION, MONITORING AND TREATMENT OF DISEASE AND CHARACTERIZATION OF BIOLOGICAL CONDITION USING GENE EXPRESSION PROFILESUS 6,964,850 · 2005 ARRAYED BIOMOLECULES AND THEIR USE IN SEQUENCINGUS 6,787,308 · 2004 IN VITRO SORTING METHODUS 6,489,103 · 2002 PARALLEL POLYNUCLEOTIDE SEQUENCING METHODUS 5,935,793 · 1999

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