SYSTEMS AND METHODS FOR GENETIC IDENTIFICATION AND ANALYSIS

Patent №

US 11,655,498

Granted

2023-05-23

Filed 2020

Owner

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

AI components

1

hardware

Assignment

Recorded

Dataset

AIPD

2023_r1 edition

Application

16629081

The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.

AI hardwareC12Q 1/6858C12Q 1/68C12Q 1/6869C12Q 1/6886G16B 20/00G16B 40/10C12Q 2600/156

AI classification

AI hardware0.59
Knowledge representation0.36
Machine learning0.13
Planning0.02
Natural language0.02
Vision0.00
Evolutionary computation0.00
Speech0.00

Ownership

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

assignment · 516280001

Assignors

RICKE, DARRELL ORLYN, HARPER, JAMES, HELFER, BRIAN S., ISAACSON, JOSEPH, MICHALEAS, ADAM M., PETROVICK, MARTHA S., SCHWOEBEL, ERIC, SHCHERBINA, ANNA, FREMONT-SMITH, PHILIP, WATKINS, JAMES G., WACK, EDWARD C.

On an employer assignment, the assignors are typically the inventors.

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