Patent №
US 11,655,498
Granted
2023-05-23
Filed 2020
Owner
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Lab
AI components
1
hardware
Assignment
Recorded
Dataset
AIPD
2023_r1 edition
Application
16629081
The disclosure provides various systems and methods for identifying individuals from one or more samples. In particular, improved systems and methods of analysis are provided for handling multiple contributors, as well as systems and methods that model not only individual error rates per locus but factor in amplification of errors induced through PCR cycles. In some embodiments, modeling of error rates can be applied in multi-contributor settings to more accurately establish real alleles from artifacts. Other aspects involve application of sequencing in error modeling. Further, methods are provided for determining the presence of common individual DNA profiles in one or more complex DNA mixtures and for deconvolution of multiple complex DNA mixtures into shared individual components.
AI classification
Ownership
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
assignment · 516280001
Assignors
RICKE, DARRELL ORLYN, HARPER, JAMES, HELFER, BRIAN S., ISAACSON, JOSEPH, MICHALEAS, ADAM M., PETROVICK, MARTHA S., SCHWOEBEL, ERIC, SHCHERBINA, ANNA, FREMONT-SMITH, PHILIP, WATKINS, JAMES G., WACK, EDWARD C.
On an employer assignment, the assignors are typically the inventors.