METHODS AND APPARATUS FOR MULTI-SPATIAL GUIDED IMAGE RECONSTRUCTION

Systems and methods for reconstructing medical images are disclosed. Measurement data from positron emission tomography (PET) data, and measurement data from an anatomy modality, such as magnetic resonance (MR) data, is received from an image scanning system. A PET image is generated based on the PET measurement data, and a plurality of anatomy images are generated based on the anatomy measurement data. The plurality of anatomy images include voxels of differing spatial resolutions. A multi-spatial image reconstruction process is applied to the PET measurement data and the plurality of anatomy images. Based on the application of the image reconstruction process, image volume data characterizing a reconstructed medical image is generated. The reconstructed medical image may be displayed to a medical professional for diagnosis.