Patent №
US 6,288,048
Granted
2001-09-11
Filed 1999
Owner
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, THE
Lab
—
AI components
1
hardware
Assignment
Recorded
Dataset
AIPD
2023_r1 edition
Application
09250785
The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
AI classification
Ownership
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, THE
assignment · 98440148
Assignors
BEACHY, PHILIP A., PORTER, JEFFREY A., COOPER, MICHAEL K.
On an employer assignment, the assignors are typically the inventors.