Optical detection system for the detection of organic molecules

An optical detection system. The optical detection system includes an integrated circuit, photosensors, a passivation layer formed above the photosensors, and test sites formed on the passivation layer. The test sites include test probes of organic material that are able to bind with target organic molecules. The combination of the test probes and target organic molecules can be activated such that light is given off from the test sites in proportion to the concentration of target molecules. Light given off from the test sites is detected by the photosensors that are present below the passivation layer. The photosensors generate electronic signals in proportion to the amount of light received from the test sites. The electronic signals are then transmitted from the photosensors to the integrated circuit for signal processing. Signal processing within the integrated circuit can enhance the quality of the electronic signals generated by the photosensors. The integrated circuit and photosensors can be fabricated utilizing known fabrication techniques, such as CMOS.