PROTEIN DESIGN AUTOMATION FOR PROTEIN LIBRARIES

Patent №

US 6,403,312

Granted

2002-06-11

Filed 1999

Owner

XENCOR, INC.

Lab

—

AI components

ml · evo · hardware

Assignment

Recorded

Dataset

AIPD

2023_r1 edition

Application

09419351

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The invention relates to the use of protein design automaton (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Machine learning Evolutionary computation AI hardwareC12N 9/86C12N 15/102C12N 15/1034C12Y 305/02006

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AI classification

Machine learning0.96

Evolutionary computation0.84

AI hardware0.53

Natural language0.17

Vision0.01

Knowledge representation0.00

Speech0.00

Planning0.00

Ownership

XENCOR, INC.

assignment · 115170330

Assignors

DAHIYAT, BASSIL I., HAYES, ROBERT J., BENTZIEN, JORG, FIEBIG, KLAUS M.

On an employer assignment, the assignors are typically the inventors.

From the same owner

FC VARIANTS WITH ALTERED BINDING TO FCRNUS 8,088,376 · 2012 METHODS OF GENERATING VARIANT ANTIBODIES WITH INCREASED HOST STRING CONTENTUS 7,657,380 · 2010 METHODS FOR RATIONAL PEGYLATION OF PROTEINSUS 7,610,156 · 2009 METHODS FOR RATIONAL PEGYLATION OF PROTEINSUS 7,587,286 · 2009 PROTEIN DESIGN AUTOMATION FOR PROTEIN LIBRARIESUS 7,315,786 · 2008 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITYUS 7,071,307 · 2006

Cites (1)

IMMOBILIZED MOLECULAR SYNTHESIS OF SYSTEMATICALLY SUBSTITUDED COMPOUNDSUS 5,527,681 · 1996

Cited by (28)

LONG FRAGMENT DE NOVO ASSEMBLY USING SHORT READSUS 10,726,942 · 2020 Templated NanoconjugatesUS 9,757,475 · 2017 TEMPLATED NANOCONJUGATESUS 9,376,690 · 2016 INDEXING A REFERENCE SEQUENCE FOR OLIGOMER SEQUENCE MAPPINGUS 8,738,296 · 2014 METHODS OF SCREENING COMPLEX PROTEIN LIBRARIES TO IDENTIFY ALTERED PROPERTIESUS 8,633,139 · 2014 OLIGOMER SEQUENCES MAPPINGUS 8,615,365 · 2013 METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONSUS 8,170,806 · 2012 METHODS FOR IDENTIFYING AND PRODUCING POLYPEPTIDESUS 7,957,912 · 2011 METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDURESUS 7,904,249 · 2011 METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONSUS 7,873,499 · 2011 METHODS FOR MAKING POLYNUCLEOTIDES HAVING DESIRED CHARACTERISTICSUS 7,853,410 · 2010 METHODS OF GENERATING VARIANT ANTIBODIES WITH INCREASED HOST STRING CONTENTUS 7,657,380 · 2010 METHODS FOR IDENTIFYING SETS OF OLIGONUCLEOTIDES FOR USE IN AN IN VITRO RECOMBINATION PROCEDUREUS 7,620,502 · 2009 METHODS FOR RATIONAL PEGYLATION OF PROTEINSUS 7,610,156 · 2009 METHODS FOR RATIONAL PEGYLATION OF PROTEINSUS 7,587,286 · 2009 METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONSUS 7,430,477 · 2008 IDENTIFYING OLIGONUCLEOTIDES FOR IN VITRO RECOMBINATIONUS 7,421,347 · 2008 PROTEIN DESIGN AUTOMATION FOR PROTEIN LIBRARIESUS 7,315,786 · 2008 APPARATUS AND METHOD FOR DESIGNING PROTEINS AND PROTEIN LIBRARIESUS 7,231,328 · 2007 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITYUS 7,071,307 · 2006 METHODS FOR MAKING CHARACTER STRINGS, POLYNUCLEOTIDES AND POLYPEPTIDES HAVING DESIRED CHARACTERISTICSUS 7,058,515 · 2006 ENSEMBLE-BASED ANALYSIS OF THE PH-DEPENDENCE OF STABILITY OF PROTEINSUS 7,027,969 · 2006 METHODS FOR MAKING CHARACTER STRINGS, POLYNUCLEOTIDES AND POLYPEPTIDES HAVING DESIRED CHARACTERISTICSUS 7,024,312 · 2006 METHODS OF POPULATING DATA STRUCTURES FOR USE IN EVOLUTIONARY SIMULATIONSUS 6,961,664 · 2005 METHODS FOR MAKING CHARACTER STRINGS, POLYNUCLEOTIDES AND POLYPEPTIDES HAVING DESIRED CHARACTERISTICSUS 6,917,882 · 2005

and 3 more

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