METHODS FOR MEASURING THERAPY RESISTANCE

Patent №

US 7,206,699

Granted

2007-04-17

Filed 2001

Owner

VIRCO N.V.

+1 more

Lab

AI components

1

kr

Assignment

Recorded

Dataset

AIPD

2023_r1 edition

Application

09836477

The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the development of resistance to one or more drugs is obtained from the generated genetic code, a genotype database is interrogated for previous samples with similar mutations relating to said one or more drugs, a phenotype for said sample is located in a phenotype database, the mean change in inhibition is determined based on all the examples located in said phenotype database, a distribution of sensitivities of one or more drugs suitable for treating a specific indication is determined.

Knowledge representationC12Q 1/6876A61P 31/18C12Q 1/703C12Q 1/707G16B 20/00G16B 30/10G16B 50/20C12Q 2600/156+4 more

AI classification

Knowledge representation0.91
Planning0.44
Machine learning0.21
AI hardware0.10
Vision0.01
Natural language0.01
Evolutionary computation0.00
Speech0.00

Ownership

VIRCO N.V.

assignment · 120570697

VIRCO BVBA

namechg · 191930686

Assignors

LARDER, BRENDAN, BLOOR, STUART, HERTOGS, KURT, DEHERTOGH, PASCALE ALFONS ROSA, MORTIER, RUDY JEAN MARC

On an employer assignment, the assignors are typically the inventors.

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