METHOD AND SYSTEM FOR QUANTIFYING AND REMOVING SPATIAL-INTENSITY TRENDS IN MICROARRAY DATA

Patent №

US 7,302,348

Granted

2007-11-27

Filed 2004

Owner

AGILENT TECHNOLOGIES, INC.

Lab

—

AI components

vision

Assignment

Recorded

Dataset

AIPD

2023_r1 edition

Application

10859868

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A method and system for quantifying and correcting spatial-intensity trends for each channel of a microarray data set having one or more channels. The method and system of one embodiment of the present invention selects a set of features from each channel of the microarray data set. Based on the selected set of features, a surface is used to determine the intensities for all features in each channel of the microarray data set. Spatial-intensity trends within the microarray data set are quantified, based on the surface to the intensities for each channel of the microarray data set. After the surface has been determined, the spatial-intensity trend can be removed from the microarray data set.

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Ownership

AGILENT TECHNOLOGIES, INC.

assignment · 184230477

Assignors

GHOSH, JAYATI, PECK, BILL J., LEPROUST, ERIC M., TROUP, CHARLES DAVID, DELENSTARR, GLENDA CHOATE, COLLINS, PATRICK J., CORSON, JOHN F., WOLBER, PAUL K., ZHOU, XIANGYANG

On an employer assignment, the assignors are typically the inventors.

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Cites (9)

AUTOMATED DNA ARRAY IMAGE SEGMENTATION AND ANALYSISUS 6,674,882 · 2004 FEATURE EXTRACTION AND NORMALIZATION ALGORITHMS FOR HIGH-DENSITY OLIGONUCLEOTIDE GENE EXPRESSION ARRAY DATAUS 6,571,005 · 2003 AUTOMATED DNA ARRAY IMAGE SEGMENTATION AND ANALYSISUS 6,349,144 · 2002 Digital Imaging System for Assays in Well Plates, Gels and BlotsUS 6,345,115 · 2002 READOUT METHOD FOR MOLECULAR BIOLOGICAL ELECTRONICALLY ADDRESSABLE ARRAYSUS 6,251,685 · 2001 MODEL-BASED FEATURE TRACKING SYSTEMUS 5,801,970 · 1998 VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESISUS 5,744,305 · 1998 METHOD AND APPARATUS FOR MICROSCOPIC SCREENING OF CYTOLOGICAL SAMPLESUS 5,581,487 · 1996 GRAY SCALE VISION METHOD AND SYSTEM UTILIZING SAMEUS 4,707,647 · 1987

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