Patent №
US 7,809,511
Granted
2010-10-05
Filed 2006
Owner
AJINOMOTO CO., INC.
Lab
—
AI components
3
kr · planning · hardware
Assignment
Recorded
Dataset
AIPD
2023_r1 edition
Application
11337580
A metabolic flux affecting substance production using cells is determined by 1) creating a stoichiometric matrix based on formulas of biochemical reactions from a substrate through a desired produced substance, 2) selecting the same number of independent metabolic fluxes from all metabolic fluxes as the degree of freedom of the stoichiometric matrix as free fluxes, 3) creating a sufficient number of random combinations of the free fluxes for a statistical analysis and calculating a metabolic flux distribution from each created combination based on the stoichiometric matrix, 4) obtaining a regression equation including a minimum number of free fluxes that shows a correlation with substance production from the calculated metabolic flux distributions by a multivariate statistical analysis, and 5) determining at least one metabolic flux affecting substance production based on a coefficient in the obtained regression equation.
AI classification
Ownership
AJINOMOTO CO., INC.
assignment · 175360569
Assignors
VAN DIEN, STEPHEN, IWATANI, SHINTARO, USUDA, YOSHIHIRO, MATSUI, KAZUHIKO, UEDA, TAKUJI, TSUJI, YUICHIRO
On an employer assignment, the assignors are typically the inventors.