Patent US 8,027,730

The present invention involves methods and systems for treatment of brain disorders using neuromodulation of brain networks. Treatment of one or more brain networks associated with a brain disorder is realized with a consideration of network dynamics and coupling effects such as indirect stimulation of non-target regions. A brain modulation system (BMS) increases, decreases, or otherwise modulates network regional activity in a differential manner. Therapy may aim to maintain electrical or chemical (relative) characteristics within a specified range. Therapy is initiated/adjusted using network functional imaging data including the use of brain network modeling. Linking rules may guide in the setting and subsequent adjusting of the therapy related to regions of brain network. Novel techniques are described for deterring the emergence of neural adaptation and of unintentional/indirect modulation arising from connectivity between network structures.