Patent №
US 8,229,673
Granted
2012-07-24
Filed 2003
Owner
GENOMATICA, INC.
+1 more
Lab
—
AI components
1
hardware
Assignment
Recorded
Dataset
AIPD
2023_r1 edition
Application
10402854
The invention provides in silico models for determining the physiological function of human cells, including human skeletal muscle cells. The models include a data structure relating a plurality of Homo sapiens reactants to a plurality of Homo sapiens reactions, a constraint set for the plurality of Homo sapiens reactions, and commands for determining a distribution of flux through the reactions that is predictive of a Homo sapiens physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. A regulated Homo sapiens reaction can be represented in a model of the invention by including a variable constraint for the regulated reaction. The invention further provides methods for making an in silico Homo sapiens model and methods for determining a Homo sapiens physiological function using a model of the invention.
AI classification
Ownership
GENOMATICA, INC.
assignment · 139510607
GT LIFE SCIENCES, INC.
assignment · 199770282
Assignors
PALSSON, BERNHARD O., FAMILI, IMANDOKHT, COVERT, MARKUS W., SCHILLING, CHRISTOPHE H.
On an employer assignment, the assignors are typically the inventors.