Guidance information indicating an operational proximity of a body-insertable device to a region of interest

Described embodiments include a system, method, and computer program product. A described system includes a receiver circuit that receives a first reference image that includes an objective landmark subsurface feature of a mammalian body part, and a second reference image that includes a present-location landmark subsurface feature of the mammalian body part. A feature matching circuit determines a substantial correspondence between the objective landmark subsurface feature and a first atlas subsurface feature, and a substantial correspondence between the present-location landmark subsurface feature and a second atlas subsurface feature. A location analysis circuit determines a fourth spatial relationship between the destination region of interest and a distal end portion of the body-insertable device deployed operationally proximate to the mammalian body part. An indicator circuit generates informational data indicative of the determined fourth spatial relationship. The system includes a computer-readable media configured to maintain the informational data.