Time Efficient ASL Imaging with Segmented Multiband Acquisition

A method for generating a perfusion weighted image using ASL with segmented acquisitions includes dividing an anatomical area of interest into slices and performing an EPI acquisition process using an MRI system to acquire a control image dataset representative of the slices. An ASL preparation process is performed using the MRI system to magnetically label protons in arterial blood water upstream from the anatomical area of interest. Following a first time period, a multi-band EPI acquisition process is performed using the MRI system to acquire a first labeled image dataset representative of a first subset of the slices. Following a second time period, another multi-band EPI acquisition process is performed using the MRI system to acquire a second labeled image dataset representative of a second subset of the slices. A perfusion weighted image is generated by subtracting the first and second labeled image dataset from the control image dataset.