MOTION CORRECTED IMAGING SYSTEM

Systems and methods are provided for detecting motion in an imaging system. A time series of volumetric images of a region of interest are captured at the imaging system. Each volumetric image of the time series of volumetric images is captured as a series of two-dimensional slices of the region of interest. A representative value is calculated for each voxel to create a representative volumetric dataset representing the region of interest. For each slice of the series of two-dimensional slices, a simulated volumetric time series is generated, including time series data for the slice and the calculated representative value at all times for the other slices of the series of two-dimensional slices. A volumetric registration is performed on each of the simulated volumetric time series to provide a set of estimated motion parameters for the slice associated with the simulated volumetric time series.