Drone Air Traffic Control over wireless networks for package pickup and delivery in an order defined by roads, highways, or streets

Drone systems and methods for package pickup and delivery include, in an air traffic control system configured to manage UAV flight in a geographic region, communicating to one or more UAVs over one or more wireless networks; directing a UAV to pick up the package at the pickup location and to deliver the package to a delivery location; and directing the UAV, in transit, to travel along at least one of a road, highway, and street for a predetermined distance and at a predetermined altitude.