DNA SEQUENCING BY MASS SPECTROMETRY VIA EXONUCLEASE DEGRADATION

Patent №

US 5,872,003

Granted

1999-02-16

Filed 1995

Owner

—

Lab

—

AI components

nlp

Assignment

None on record

Dataset

AIPD

2023_r1 edition

Application

08453499

Methods for determining the sequence of nucleic acids by cleaving the nucleic acid unilaterally from a first end with an exonuclease activity to sequentially release individual nucleotides, identifying each of the sequentially release nucleotides by mass spectrometry, and determining the sequence of the nucleic acid from the identified nucleotides are disclosed. The method is amenable to multiplexing for simulataneously determining more than one nuleic acid sequence.

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